Fast dissolving tablets are solid dosage forms containing medicinal substances which disintegrate rapidly usually within few seconds when placed upon tongue requiring no additional water to facilitate swallowing. Drug release from these systems is very fast and reproducible as the superdisintegrants play a vital role in the formulation. Superdisintegrants are responsible to disintegrate the tablet into small particles, which in turn increases the surface area for dissolution, thereby increasing the dissolution rate of poorly soluble drugs. Though a wide range of superdisintegrants are available there is a continued need to develop new, safe superdisintegrants for fast dissolving tablets. In the present investigation, starch maleate, a new starch based superdisintegrant was prepared and evaluated for its application in the design of a poorly soluble drug, telmisartan by employing 23 factorial design.
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